HIV-1 gp120 and human platelet glycoprotein GPIIIa: does structural homology exist?
نویسنده
چکیده
Chronic thrombocytopenia is a common hematologic disorder in patients infected with the human immunodeficiency virus (HIV). Although often asymptomatic, the thrombocytopenia may be associated with a variety of bleeding abnormalities. Antigenic homology between HIV-1 gp120 and human platelet glycoprotein GPIIIa was reported. Here, the author performed a study to assess the structural homology between HIV-1 gp120 and human platelet glycoprotein GPIIIa. To answer this question, a computer-based study for amino acid sequence comparison and protein structure modeling is performed. According to this study, gp-120 is totally difference from human platelet glycoprotein GPIIIa. It seems that the structural homology between HIV-1 gp120 and human platelet glycoprotein GPIIIa might not exist. This implies that gp-120 might not be an important underlying factor for ITP in HIV-infected patients.
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